But Problems with Blood Clots May Be More Common in Older Women, PRS Study Suggests

Older women don't have an increased overall risk of complications from breast reconstruction after mastectomy, reports the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

"Older patients should be counseled that their age does not confer an increased risk of complications after implant-based post-mastectomy breast reconstruction," concludes the study by ASPS member surgeon Mark Sisco, MD, of NorthShore University HealthSystem and University of Chicago and colleagues. However, the results do suggest that women aged 65 or older are at increased risk of blood clot-related complications after tissue-based breast reconstruction.

No Difference in Overall Complications by Age…

Using a national surgery database, the researchers identified nearly 41,100 women who had unilateral mastectomy (removal of one breast) between 2005 and 2012. Of these, about 11,800 patients underwent breast reconstruction. Women aged 65 or older were less likely to have breast reconstruction: 10.8 percent, compared to 39.5 percent for younger women.

Compared to mastectomy only, women undergoing breast reconstruction had more complications, including increased hospital days and repeat surgeries. The complication rate after breast reconstruction was 6.8 percent for older women and 5.2 percent for younger women.

The overall risk of complications did not differ significantly between age groups, after adjustment for other factors. The risk remained the same for older and younger women undergoing breast reconstruction using implants.

…But Higher VTE Risk in Older Women after Autologous Reconstruction

However, after autologous reconstruction—creation of a new breast using the patient's own tissues—the risk of blood clot-related complications called venous thromboembolism (VTE) was significantly higher for older women. VTE is a common and serious condition in which blood clots form in the leg or other veins (deep vein thrombosis) or lung (pulmonary embolism).

On adjusted analysis, VTE risk was nearly four times higher in women aged 65 or older, and more than six times higher for those aged 70 to 75. The overall rate of VTE after autologous reconstruction was just under one percent. Other types of complications were similar between age groups.

Breast reconstruction "is an important option for women undergoing mastectomy and may improve patient self-esteem, body image, and quality of life," the researchers write. Older women are much less likely to undergo breast reconstruction—partly because of a perceived increase in surgical risk.

While older women may have reasons for not undergoing breast reconstruction, there's little evidence on how age affects complication risk. "As such, it is impossible for older women to make informed decisions about the risks and benefits of post-mastectomy breast reconstruction that take into account their age," according to Dr Sisco and colleagues.

The new study shows a similar overall complication rate for older versus younger women undergoing breast reconstruction. "Older women considering implant-based reconstruction should be assured that their age is not a factor in determining the risk of complications," the researchers write.

"However, they should be counseled that their age may confer an increased risk of VTE," Dr Sisco and coauthors add. They suggest that older women may need special attention to preventing VTE after autologous breast reconstruction—possibly including longer use of blood-thinning medications.

Plastic and Reconstructive Surgery® is published by Lippincott Williams & Wilkins, part of Wolters Kluwer Health.

About Plastic and Reconstructive Surgery

For more than 60 years, Plastic and Reconstructive Surgery (PRS)® has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. The official journal of the American Society of Plastic Surgeons, PRS brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair, and cosmetic surgery, as well as news on medico-legal issues.

About Wolters Kluwer Health

Wolters Kluwer Health is a leading global provider of information, business intelligence and point-of-care solutions for the healthcare industry. Serving more than 150 countries and territories worldwide, Wolters Kluwer Health’s customers include professionals, institutions and students in medicine, nursing, allied health and pharmacy. Major brands include Health Language®, Lexicomp®, Lippincott Williams & Wilkins, Medicom®, Medknow, Ovid®, Pharmacy OneSource®, ProVation® Medical and UpToDate®.

Wolters Kluwer Health is part of Wolters Kluwer, a market-leading global information services company. Wolters Kluwer had 2012 annual revenues of €3.6 billion ($4.6 billion), employs approximately 19,000 people worldwide, and maintains operations in over 40 countries across Europe, North America, Asia Pacific and Latin America. Follow our official Twitter handle: @WKHealth.

About ASPS

The American Society of Plastic Surgeons (ASPS) is the world's largest organization of board-certified plastic surgeons. Representing more than 7,000 Member Surgeons, the Society is recognized as a leading authority and information source on aesthetic and reconstructive plastic surgery. ASPS comprises more than 94 percent of all board-certified plastic surgeons in the United States. Founded in 1931, the Society represents physicians certified by The American Board of Plastic Surgery or The Royal College of Physicians and Surgeons of Canada. ASPS advances quality care to plastic surgery patients by encouraging high standards of training, ethics, physician practice and research in plastic surgery. 

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