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Blood Thinner Lowers Clot Risk in Plastic Surgery Patients
In Highest-Risk Group, Enoxaparin Reduces Venous Thromboembolism Rate by 60 Percent

Arlington Heights, Ill. - For plastic surgery patients at high risk, treatment with the anticoagulant (blood-thinning) drug enoxaparin can reduce the risk of serious blood clot-related complications called venous thromboembolism (VTE), reports a study in the November issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

The results suggest that enoxaparin could help to meet one of the most important safety goals in plastic surgery today: preventing serious VTEs in high-risk patients. Funded by The Plastic Surgery Foundation, the study was performed by a consortium of U.S. plastic surgeons. The lead author was Christopher J. Pannucci, MD of University of Michigan, Ann Arbor.

Enoxaparin Reduces VTE Risk in Patients at Highest Risk

Venous thromboembolism is a potentially serious complication in which clots develop, blocking blood flow to the legs (deep vein thrombosis) or lungs (pulmonary embolism). In addition to the immediate risk of death, VTE can lead to long-term complications and health problems.

The Venous Thromboembolism Prevention Study (VTEPS) included 3,334 patients undergoing plastic and reconstructive surgery at four U.S. hospitals. All were considered at increased risk of VTE, scoring three or higher on a standard VTE risk scale (Caprini risk assessment model). The Caprini score was based on a number of known risk factors such as older age, certain types of heart or lung disease, a recent history of VTE and other medical conditions.

All patients enrolled in the VTEPS were treated with enoxaparin-a type of the blood-thinning drug heparin that has been approved for use in patients at risk of VTE. Rates of VTE within 60 days after surgery were compared with those of similar patients undergoing plastic surgery at the same hospitals without preventive enoxaparin.

Enoxaparin appeared to reduce the rate of VTE among patients at highest risk: those with a Caprini score over 8. In this group, VTE occurred in about four percent of patients receiving enoxaparin, compared to 8.5 percent of similar patients who did not receive enoxaparin.

After adjustment for the Caprini score and other important risk factors, patients receiving enoxaparin were about 60 percent less likely to develop VTE.

Enoxaparin appeared to reduce the rate of VTE among patients in the highest category of risk. When the Caprini risk score was over 8, VTE occurred in about four percent of patients receiving enoxaparin, compared to 8.5 percent of patients not receiving enoxaparin.

With adjustment for other risk factors, the VTE rate was nearly tripled for patients with a Caprini score over 8. For patients with a prolonged hospital stay of four days or longer-an indicator of more severe illness-VTE risk was close to five times higher. When accounting for these two factors, treatment with enoxaparin reduced the relative risk of VTE by about 60 percent.

Venous thromboembolism is a major safety issue in surgical patients. A recent study found that rates of VTE in plastic surgery are higher than previously thought. Studies have suggested that most plastic surgeons know how to identify patients at increased risk of VTE, but don't always don't provide adequate preventive measures. In response to this concern, The Plastic Surgery Foundation rated VTE risk assessment and prevention as its top patient safety research priority.

The VTEPS results suggest that enoxaparin is effective in reducing the rate of VTE among plastic surgery patients at highest risk. Based on data from patients undergoing other types of surgery, current recommendations call for high-risk patients to receive a full week of postoperative anticoagulant treatment. Further studies will be needed to determine the optimal duration of enoxaparin therapy in patients undergoing plastic surgery.

Plastic and Reconstructive Surgery® is published by Lippincott Williams & Wilkins, part of Wolters Kluwer Health.

About Plastic and Reconstructive Surgery

For over 75 years, Plastic and Reconstructive Surgery® has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. The official journal of the American Society of Plastic Surgeons, Plastic and Reconstructive Surgery® brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair and cosmetic surgery, as well as news on medico-legal issues.

About ASPS

The American Society of Plastic Surgeons (ASPS) is the largest organization of board-certified plastic surgeons in the world. Representing more than 11,000 physician members worldwide, the society is recognized as a leading authority and information source on cosmetic and reconstructive plastic surgery. ASPS comprises more than 92 percent of all board-certified plastic surgeons in the United States. Founded in 1931, the society represents physicians certified by the American Board of Plastic Surgery or the Royal College of Physicians and Surgeons of Canada.

About Wolters Kluwer

Wolters Kluwer (EURONEXT: WKL) is a global leader in professional information, software solutions and services for the healthcare, tax and accounting, financial and corporate compliance, legal and regulatory and corporate performance and ESG sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with specialized technology and services.

Wolters Kluwer reported 2022 annual revenues of €5.5 billion. The group serves customers in over 180 countries, maintains operations in over 40 countries and employs approximately 20,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands.

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