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Good Breast Reconstruction Outcomes After Nipple-Sparing Mastectomy, Reports PRS
Increasingly Popular Breast Cancer Treatment Option Promotes Immediate Reconstruction with Low Complication Rates

Arlington Heights, Ill. -- "Nipple-sparing" techniques are a safe and effective option for mastectomy with immediate breast reconstruction, reports a study in the March issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

ASPS Member Surgeon Dr. Amy S. Colwell and colleagues of Massachusetts General Hospital conducted a large study observing outcomes of nipple-sparing mastectomy and immediate breast reconstruction in women undergoing surgery for treatment or prevention of breast cancer. They write, "Our review demonstrates that nipple-sparing mastectomy and immediate reconstruction has a high rate of success and a low rate of complications."

Good Reconstruction Outcomes after Nipple-Sparing Mastectomy

Nipple-sparing procedures are an increasingly popular alternative for women undergoing mastectomy. Using this technique, the surgeon preserves the nipple and surrounding tissues for use in immediate breast reconstruction. In patients being treated for breast cancer, nipple-sparing mastectomy can be performed only if the nipple and surrounding tissues are completely free of cancer.

Between 2007 and 2012, Dr. Colwell and colleagues performed a total of 500 nipple-sparing mastectomies in 285 women, average age 46 years. Fifty-four percent of the women underwent "risk-reducing" mastectomy because of high genetic risk of breast cancer.

Nearly all of the women underwent immediate breast reconstruction, usually with implants. In about 60 percent of patients, breast reconstruction with implants was completed at the same time as mastectomy. Most of the remaining women underwent two-stage reconstruction, including tissue expansion to increase the amount of skin available for implant-based reconstruction.

The overall complication rate was about 12 percent. The most common complications were tissue death (necrosis) of part of the nipple or skin used for reconstruction. Cancer involving the nipple area was discovered in another four percent of women. Even including these cases, the natural nipple was retained in the final reconstruction in more than 90 percent of cases.

Smoking, Radiation and Incision Type Affect Complication Rate

The study identified several important risk factors for complications. The complication rate was more than three times higher for women who smoked. Women who had received radiation therapy were also at increased risk.

Complications were also more common when the incision was placed around the nipple (periareolar incision). In contrast, the more commonly used incision under the breast fold (inframammary incision) was associated with a lower complication rate.

Nipple-sparing mastectomy has been "gaining traction as a preferred surgical option" for breast cancer treatment and for preventive mastectomy in women at high risk of breast cancer. It offers effective control of breast cancer risk while preserving the patient's natural tissues for breast reconstruction. The new study is one of the first to detail the outcomes of breast reconstruction after nipple-sparing mastectomy.

With current techniques, the risk of complications appears lower than in initial reports of nipple-sparing mastectomy. At Massachusetts General Hospital, cancer surgeons and plastic surgeons follow a team approach to effectively control breast cancer risk while maximizing reconstruction outcomes.

"We are performing an increasing number of nipple-sparing mastectomy procedures as more breast oncology surgeons become comfortable with the procedure and with expansion of our indications for nipple-sparing surgery," Dr. Colwell and coauthors write. They increasingly use the inframammary incision based on patient preference, as well as the lower complication rate. The researchers add that they now perform single-stage reconstruction in more than two-thirds of women undergoing nipple-sparing mastectomy.

Plastic and Reconstructive Surgery is published by Lippincott Williams & Wilkins, part of Wolters Kluwer Health.

About Plastic and Reconstructive Surgery

For over 75 years, Plastic and Reconstructive Surgery® has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. The official journal of the American Society of Plastic Surgeons, Plastic and Reconstructive Surgery® brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair and cosmetic surgery, as well as news on medico-legal issues.

About ASPS

The American Society of Plastic Surgeons (ASPS) is the largest organization of board-certified plastic surgeons in the world. Representing more than 11,000 physician members worldwide, the society is recognized as a leading authority and information source on cosmetic and reconstructive plastic surgery. ASPS comprises more than 92 percent of all board-certified plastic surgeons in the United States. Founded in 1931, the society represents physicians certified by the American Board of Plastic Surgery or the Royal College of Physicians and Surgeons of Canada.

About Wolters Kluwer

Wolters Kluwer (EURONEXT: WKL) is a global leader in professional information, software solutions and services for the healthcare, tax and accounting, financial and corporate compliance, legal and regulatory and corporate performance and ESG sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with specialized technology and services.

Wolters Kluwer reported 2022 annual revenues of €5.5 billion. The group serves customers in over 180 countries, maintains operations in over 40 countries and employs approximately 20,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands.

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