American Society of Plastic Surgeons
For Medical Professionals

Ten Percent Rate of Prolonged Opioid Use After Breast Reconstruction

Ten percent of women who undergo mastectomy and immediate breast reconstruction are still taking prescription opioid pain medications three months after surgery, suggests a study in the December issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

Prolonged opioid use is common after breast reconstruction, according to the research by Jennifer F. Waljee, MD, MPH, MS, and colleagues of University of Michigan, Ann Arbor. They urge plastic and reconstructive surgeons to be aware of the risk of persistent opioid use after breast reconstruction, and to seek alternative methods of postoperative pain control when possible.

Opioid Use Persists for Many Breast Reconstruction Patients

Using a health benefits claims database, the researchers identified 4,113 women who underwent mastectomy for breast cancer and immediate breast reconstruction between 2010 and 2014. All patients were "opioid-naive," with no opioid prescriptions within the previous year.

Pharmacy claims data showed that 90 percent of patients filled an opioid prescription after breast reconstruction. That was consistent with previous studies reporting high rates of opioid use after other common, "low-risk" surgical procedures.

Three months later, ten percent of women continued to fill an opioid prescription. Prolonged opioid use was more common for women diagnosed with anxiety and for those who experienced some type of complication—most commonly infection.

Prolonged opioid use was less likely for women receiving chemotherapy, and for those undergoing breast reconstruction using their own tissues (autologous reconstruction), as opposed to implants. About three-fourths of the women had breast reconstruction using implants. Women diagnosed with depression received higher doses of opioids, as did those who underwent reconstruction of both breasts (bilateral reconstruction). Opioid doses were lower for women aged 55 to 64, compared to younger patients.

As for many types of surgery, opioids are the "mainstay" for pain control after mastectomy and breast reconstruction. Amid the ongoing opioid crisis, there is increased attention to the risk of dependence and prolonged use of opioids prescribed after surgery. Most opioid prescribing guidelines focus on patients with chronic pain, rather than postoperative pain. Patients with cancer may be especially susceptible to opioid dependence. Breast reconstruction is the most common type of cancer reconstruction—US plastic surgeons performed more than 109,000 breast reconstructions in 2016, according to ASPS statistics.

The new study focuses attention on the large number of women who continue to take opioids several months after breast reconstruction. It also identifies patient- and procedure-related risk factors for prolonged or higher-dose opioid use, including implant-based breast reconstruction, bilateral reconstruction, and anxiety or depression.

Dr. Waljee and coauthors conclude, "Close consultation with providers in primary care, psychiatry, and pain management during the postoperative period can provide more coordinated care with opioid alternatives for these complex and potentially vulnerable patients."

Plastic and Reconstructive Surgery® is published by Wolters Kluwer.

Click here to read "Prescription Opioid Use among Opioid-Naive Women Undergoing Immediate Breast Reconstruction"

Article: "Prescription Opioid Use among Opioid-Naive Women Undergoing Immediate Breast Reconstruction" (doi: 10.1097/PRS.0000000000003832)

About Plastic and Reconstructive Surgery

For more than 70 years, Plastic and Reconstructive Surgery® has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. The official journal of the American Society of Plastic Surgeons, Plastic and Reconstructive Surgery® brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair, and cosmetic surgery, as well as news on medico-legal issues.

About ASPS

The American Society of Plastic Surgeons (ASPS) is the world's largest organization of board-certified plastic surgeons. Representing more than 8,000 member surgeons, the Society is recognized as a leading authority and information source on aesthetic and reconstructive plastic surgery. ASPS comprises more than 93 percent of all board-certified plastic surgeons in the United States. Founded in 1931, the Society represents physicians certified by The American Board of Plastic Surgery or The Royal College of Physicians and Surgeons of Canada. ASPS advances quality care to plastic surgery patients by encouraging high standards of training, ethics, physician practice and research in plastic surgery.

About Wolters Kluwer

Wolters Kluwer is a global leader in professional information services. Professionals in the areas of legal, business, tax, accounting, finance, audit, risk, compliance and healthcare rely on Wolters Kluwer's market leading information-enabled tools and software solutions to manage their business efficiently, deliver results to their clients, and succeed in an ever more dynamic world.

Wolters Kluwer reported 2015 annual revenues of €4.2 billion. The group serves customers in over 180 countries, and employs over 19,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands. Wolters Kluwer shares are listed on Euronext Amsterdam (WKL) and are included in the AEX and Euronext 100 indices. Wolters Kluwer has a sponsored Level 1 American Depositary Receipt program. The ADRs are traded on the over-the-counter market in the U.S. (WTKWY).

Wolters Kluwer Health is a leading global provider of information and point of care solutions for the healthcare industry. For more information about our products and organization, visit, follow @WKHealth or @Wolters_Kluwer on Twitter, like us on Facebook, follow us on LinkedIn, or follow WoltersKluwerComms on YouTube.


Patient Care Center